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Gene: PRSS2 (serine protease 2) Homo sapiens
Symbol: PRSS2
Name: serine protease 2
Description: Exhibits calcium ion binding activity and serine-type endopeptidase activity. Involved in collagen catabolic process and proteolysis. Localizes to extracellular space. Biomarker of cholangiocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: anionic trypsinogen; MGC111183; MGC120174; MGC120175; protease serine 2 preproprotein; protease, serine 2; protease, serine, 2 (trypsin 2); protease, serine, 2, preproprotein; TRY2; TRY8; TRYP2; trypsin 2; trypsin II; trypsin-2; trypsinogen 2
Mus musculus (house mouse) : Prss2 (protease, serine 2)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : PRSS2 (serine protease 2)
Sus scrofa (pig) : PRSS2 (serine protease 2)
Chlorocebus sabaeus (African green monkey) : PRSS2 (serine protease 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl7142,760,398 - 142,774,564 (+)EnsemblGRCh38hg38GRCh38
GRCh387142,770,970 - 142,774,560 (+)NCBIGRCh38GRCh38hg38GRCh38
Build 367142,178,778 - 142,182,363 (+)NCBINCBI36hg18NCBI36
Build 347141,985,492 - 141,989,078NCBI
Celera7137,305,959 - 137,309,542 (+)NCBI
Cytogenetic Map7q34NCBI
HuRef7136,807,313 - 136,810,896 (+)NCBIHuRef
CHM1_17142,404,915 - 142,408,536 (+)NCBICHM1_1
CRA_TCAGchr7v27141,870,508 - 141,874,093NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRSS2
Alliance Gene
Ensembl Gene
JBrowse: hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347326
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.