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Gene: HLA-G (major histocompatibility complex, class I, G) Homo sapiens
Symbol: HLA-G
Name: major histocompatibility complex, class I, G
CRRD ID: 1347423
Description: Exhibits CD8 receptor binding activity; peptide antigen binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of leukocyte mediated cytotoxicity; positive regulation of cytokine production; and regulation of leukocyte differentiation. Localizes to cis-Golgi network membrane; early endosome; and plasma membrane. Implicated in asthma and hepatitis C. Biomarker of allergic rhinitis; cystic fibrosis; and respiratory syncytial virus infectious disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: b2 microglobulin; HLA class I histocompatibility antigen, alpha chain G; HLA class I molecule; HLA G antigen; HLA-G histocompatibility antigen, class I, G; MHC class I antigen; MHC class I antigen G; MHC class Ib antigen; MHC-G; mutant MHC class I antigen; mutant MHC class Ib antigen
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl629,826,967 - 29,831,125 (+)EnsemblGRCh38hg38GRCh38
GRCh38629,826,474 - 29,831,130 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37629,794,756 - 29,798,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36629,903,497 - 29,906,859 (+)NCBINCBI36hg18NCBI36
Build 34629,903,496 - 29,906,859NCBI
Celera631,397,875 - 31,402,019 (+)NCBI
Cytogenetic Map6p22.1NCBI
HuRef629,598,096 - 29,602,239 (+)NCBIHuRef
CHM1_1629,796,551 - 29,800,708 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

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