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Gene: SOCS1 (suppressor of cytokine signaling 1) Homo sapiens
Symbol: SOCS1
Name: suppressor of cytokine signaling 1
Description: Exhibits insulin-like growth factor receptor binding activity and protein kinase binding activity. Involved in negative regulation of tyrosine phosphorylation of STAT protein and positive regulation of regulatory T cell differentiation. Localizes to cytoplasmic ribonucleoprotein granule and nucleoplasm. Implicated in ovarian carcinoma; prostate cancer; and urinary bladder cancer. Biomarker of ductal carcinoma in situ; human immunodeficiency virus infectious disease; and invasive ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CIS1; CISH1; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; SOCS-1; SSI-1; SSI1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Tec-interacting protein 3; TIP-3; TIP3
Mus musculus (house mouse) : Socs1 (suppressor of cytokine signaling 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Socs1 (suppressor of cytokine signaling 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs1 (suppressor of cytokine signaling 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS1 (suppressor of cytokine signaling 1)
Canis lupus familiaris (dog) : SOCS1 (suppressor of cytokine signaling 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs1 (suppressor of cytokine signaling 1)
Sus scrofa (pig) : SOCS1 (suppressor of cytokine signaling 1)
Chlorocebus sabaeus (African green monkey) : SOCS1 (suppressor of cytokine signaling 1)
Heterocephalus glaber (naked mole-rat) : Socs1 (suppressor of cytokine signaling 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1611,254,408 - 11,256,204 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl1611,254,405 - 11,256,200 (-)EnsemblGRCh38hg38GRCh38
GRCh381611,254,417 - 11,256,182 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371611,348,274 - 11,350,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,255,775 - 11,257,540 (-)NCBINCBI36hg18NCBI36
Build 341611,255,774 - 11,257,540NCBI
Celera1611,517,679 - 11,519,444 (-)NCBI
Cytogenetic Map16p13.13NCBI
HuRef1611,266,017 - 11,267,782 (-)NCBIHuRef
CHM1_11611,348,201 - 11,349,966 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SOCS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347441
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.