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Gene: PHF8 (PHD finger protein 8) Homo sapiens
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Symbol: PHF8
Name: PHD finger protein 8
CRRD ID: 1347460
Description: Exhibits several functions, including histone demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Involved in G1/S transition of mitotic cell cycle; histone lysine demethylation; and positive regulation of transcription, DNA-templated. Localizes to nuclear membrane; nucleolus; and nucleoplasm. Implicated in syndromic X-linked intellectual disability Siderius type. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8; DKFZp686E0868; histone lysine demethylase PHF8; JHDM1F; jumonji C domain-containing histone demethylase 1F; KDM7B; KIAA1111; MRXSSD; ZNF422
Orthologs:
Mus musculus (house mouse) : Phf8 (PHD finger protein 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Phf8 (PHD finger protein 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phf8 (PHD finger protein 8)
Pan paniscus (bonobo/pygmy chimpanzee) : PHF8 (PHD finger protein 8)
Canis lupus familiaris (dog) : PHF8 (PHD finger protein 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phf8 (PHD finger protein 8)
Sus scrofa (pig) : PHF8 (PHD finger protein 8)
Chlorocebus sabaeus (African green monkey) : PHF8 (PHD finger protein 8)
Heterocephalus glaber (naked mole-rat) : Phf8 (PHD finger protein 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX53,936,676 - 54,048,958 (-)EnsemblGRCh38hg38GRCh38
GRCh38X53,936,680 - 54,048,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X53,963,113 - 54,075,368 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,979,838 - 54,087,036 (-)NCBINCBI36hg18NCBI36
Build 34X53,846,135 - 53,953,332NCBI
CeleraX57,794,656 - 57,902,802 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX51,017,153 - 51,124,050 (-)NCBIHuRef
CHM1_1X53,954,083 - 54,062,605 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PHF8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347460
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.