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Gene: LILRB4 (leukocyte immunoglobulin like receptor B4) Homo sapiens
Symbol: LILRB4
Name: leukocyte immunoglobulin like receptor B4
CRRD ID: 1347745
Description: Predicted to have antigen binding activity and signaling receptor activity. Involved in several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of pri-miRNA transcription by RNA polymerase II; and regulation of leukocyte differentiation. Localizes to extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD85 antigen-like family member K; CD85K; HM18; ILT-3; ILT3; immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; leukocyte immunoglobulin-like receptor 5; leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor subfamily B member 4 soluble isoform; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4; LILRB5; LIR-5; LIR5; monocyte inhibitory receptor HM18
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1954,643,889 - 54,670,359 (+)EnsemblGRCh38hg38GRCh38
GRCh381954,662,524 - 54,670,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371955,174,271 - 55,181,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361959,865,936 - 59,871,660 (+)NCBINCBI36hg18NCBI36
Build 341959,866,263 - 59,873,621NCBI
Celera1952,214,265 - 52,220,001 (+)NCBI
Cytogenetic Map19q13.42NCBI
HuRef1951,497,246 - 51,504,797 (+)NCBIHuRef
CHM1_11955,167,838 - 55,175,378 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LILRB4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347745
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.