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Gene: AICDA (activation induced cytidine deaminase) Homo sapiens
Symbol: AICDA
Name: activation induced cytidine deaminase
Description: Exhibits cytidine deaminase activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Involved in DNA demethylation; regulation of cellular macromolecule biosynthetic process; and somatic hypermutation of immunoglobulin genes. Localizes to cytoplasm; nucleus; and protein-containing complex. Implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Biomarker of acute lymphoblastic leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activation-induced cytidine deaminase; AID; ARP2; CDA2; cytidine aminohydrolase; epididymis secretory protein Li 284; HEL-S-284; HIGM2; integrated into Burkitt's lymphoma cell line Ramos; single-stranded DNA cytosine deaminase
Mus musculus (house mouse) : Aicda (activation-induced cytidine deaminase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aicda (activation-induced cytidine deaminase)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : AICDA (activation induced cytidine deaminase)
Canis lupus familiaris (dog) : AICDA (activation induced cytidine deaminase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aicda (activation induced cytidine deaminase)
Sus scrofa (pig) : AICDA (activation induced cytidine deaminase)
Chlorocebus sabaeus (African green monkey) : AICDA (activation induced cytidine deaminase)
Heterocephalus glaber (naked mole-rat) : Aicda (activation induced cytidine deaminase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl128,602,170 - 8,612,867 (-)EnsemblGRCh38hg38GRCh38
GRCh38128,602,170 - 8,612,970 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37128,754,762 - 8,765,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,646,029 - 8,656,706 (-)NCBINCBI36hg18NCBI36
Build 34128,646,028 - 8,656,706NCBI
Celera1210,292,343 - 10,303,027 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef128,537,559 - 8,548,246 (-)NCBIHuRef
CHM1_1128,723,739 - 8,734,421 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AICDA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347771
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.