Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CACNA1B (calcium voltage-gated channel subunit alpha1 B) Homo sapiens
Analyze
Symbol: CACNA1B
Name: calcium voltage-gated channel subunit alpha1 B
CRRD ID: 1347795
Description: Exhibits high voltage-gated calcium channel activity and protein C-terminus binding activity. Involved in modulation of chemical synaptic transmission and response to amyloid-beta. Predicted to localize to membrane. Implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Biomarker of multiple sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BIII; brain calcium channel III; CACNL1A5; CACNN; calcium channel alpha12.2 subunit; calcium channel, L type, alpha-1 polypeptide; calcium channel, N type; calcium channel, voltage-dependent, alpha 1B subunit, N type; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit; Cav2.2; Cav2.2 voltage-gated Ca2+ channel; DYT23; NEDNEH; voltage-dependent N-type calcium channel subunit alpha-1B; voltage-gated calcium channel alpha subunit Cav2.2; voltage-gated calcium channel subunit alpha Cav2.2
Orthologs:
Mus musculus (house mouse) : Cacna1b (calcium channel, voltage-dependent, N type, alpha 1B subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cacna1b (calcium voltage-gated channel subunit alpha1 B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cacna1b (calcium voltage-gated channel subunit alpha1 B)
Pan paniscus (bonobo/pygmy chimpanzee) : CACNA1B (calcium voltage-gated channel subunit alpha1 B)
Canis lupus familiaris (dog) : CACNA1B (calcium voltage-gated channel subunit alpha1 B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cacna1b (calcium voltage-gated channel subunit alpha1 B)
Sus scrofa (pig) : CACNA1B (calcium voltage-gated channel subunit alpha1 B)
Chlorocebus sabaeus (African green monkey) : CACNA1B (calcium voltage-gated channel subunit alpha1 B)
Heterocephalus glaber (naked mole-rat) : Cacna1b (calcium voltage-gated channel subunit alpha1 B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9137,877,782 - 138,124,624 (+)EnsemblGRCh38hg38GRCh38
GRCh389137,877,782 - 138,124,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379140,772,241 - 141,019,076 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,892,062 - 140,136,449 (+)NCBINCBI36hg18NCBI36
Build 349138,048,077 - 138,292,468NCBI
Cytogenetic Map9q34.3NCBI
HuRef9110,240,583 - 110,486,666 (+)NCBIHuRef
CHM1_19140,920,972 - 141,166,813 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CACNA1B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347795
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.