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Gene: PPP3CC (protein phosphatase 3 catalytic subunit gamma) Homo sapiens
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Symbol: PPP3CC
Name: protein phosphatase 3 catalytic subunit gamma
Description: Exhibits calmodulin-dependent protein phosphatase activity. Involved in calcineurin-NFAT signaling cascade and protein dephosphorylation. Localizes to cytoplasm. Implicated in schizophrenia. Biomarker of schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: calcineurin, testis-specific catalytic subunit; calmodulin-dependent calcineurin A subunit gamma isoform; CALNA3; CAM-PRP catalytic subunit; CNA3; PP2Bgamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform; protein phosphatase 3 (formerly 2b), catalytic subunit, gamma isoform (calcineurin a gamma); serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Orthologs:
Mus musculus (house mouse) : Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppp3cc (protein phosphatase 3 catalytic subunit gamma)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppp3cc (protein phosphatase 3 catalytic subunit gamma)
Pan paniscus (bonobo/pygmy chimpanzee) : PPP3CC (protein phosphatase 3 catalytic subunit gamma)
Canis lupus familiaris (dog) : PPP3CC (protein phosphatase 3 catalytic subunit gamma)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppp3cc (protein phosphatase 3 catalytic subunit gamma)
Sus scrofa (pig) : PPP3CC (protein phosphatase 3 catalytic subunit gamma)
Chlorocebus sabaeus (African green monkey) : PPP3CC (protein phosphatase 3 catalytic subunit gamma)
Heterocephalus glaber (naked mole-rat) : Ppp3cc (protein phosphatase 3 catalytic subunit gamma)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl822,440,819 - 22,541,142 (+)EnsemblGRCh38hg38GRCh38
GRCh38822,441,053 - 22,541,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37822,298,483 - 22,398,657 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,354,541 - 22,454,583 (+)NCBINCBI36hg18NCBI36
Build 34822,354,540 - 22,454,580NCBI
Celera821,260,229 - 21,360,247 (+)NCBI
Cytogenetic Map8p21.3NCBI
HuRef820,840,793 - 20,940,821 (+)NCBIHuRef
CHM1_1822,500,579 - 22,601,011 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

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Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PPP3CC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347828
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.