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Gene: SETX (senataxin) Homo sapiens
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Symbol: SETX
Name: senataxin
Description: Exhibits identical protein binding activity and transcription termination site sequence-specific DNA binding activity. Involved in several processes, including intracellular signal transduction; nucleic acid metabolic process; and positive regulation of RNA metabolic process. Localizes to several cellular components, including the growth cone; intercellular bridge; and nuclear lumen. Implicated in amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS4; amyotrophic lateral sclerosis 4; AOA2; bA479K20.2; DKFZp781B151; FLJ12840; FLJ43459; KIAA0625; probable helicase senataxin; SCAN2; SCAR1; Sen1; SEN1 homolog; spinocerebellar ataxia, recessive, non-Friedreich type 1
Orthologs:
Mus musculus (house mouse) : Setx (senataxin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Setx (senataxin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Setx (senataxin)
Pan paniscus (bonobo/pygmy chimpanzee) : SETX (senataxin)
Canis lupus familiaris (dog) : SETX (senataxin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Setx (senataxin)
Sus scrofa (pig) : SETX (senataxin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389132,261,356 - 132,356,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379135,136,827 - 135,232,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,126,648 - 134,220,193 (-)NCBINCBI36hg18NCBI36
Build 349132,168,836 - 132,259,926NCBI
Celera9105,678,763 - 105,772,221 (-)NCBI
Cytogenetic Map9q34.13NCBI
HuRef9104,630,757 - 104,723,804 (-)NCBIHuRef
CHM1_19135,286,879 - 135,380,398 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SETX
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347866
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.