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Gene: SETX (senataxin) Homo sapiens
Symbol: SETX
Name: senataxin
Description: Exhibits identical protein binding activity and transcription termination site sequence-specific DNA binding activity. Involved in several processes, including intracellular signal transduction; nucleic acid metabolic process; and positive regulation of RNA metabolic process. Localizes to several cellular components, including the growth cone; intercellular bridge; and nuclear lumen. Implicated in amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS4; amyotrophic lateral sclerosis 4; AOA2; bA479K20.2; DKFZp781B151; FLJ12840; FLJ43459; KIAA0625; probable helicase senataxin; SCAN2; SCAR1; Sen1; SEN1 homolog; spinocerebellar ataxia, recessive, non-Friedreich type 1
Mus musculus (house mouse) : Setx (senataxin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Setx (senataxin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Setx (senataxin)
Pan paniscus (bonobo/pygmy chimpanzee) : SETX (senataxin)
Canis lupus familiaris (dog) : SETX (senataxin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Setx (senataxin)
Sus scrofa (pig) : SETX (senataxin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389132,261,356 - 132,356,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379135,136,827 - 135,232,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,126,648 - 134,220,193 (-)NCBINCBI36hg18NCBI36
Build 349132,168,836 - 132,259,926NCBI
Celera9105,678,763 - 105,772,221 (-)NCBI
Cytogenetic Map9q34.13NCBI
HuRef9104,630,757 - 104,723,804 (-)NCBIHuRef
CHM1_19135,286,879 - 135,380,398 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SETX
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347866
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.