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Gene: CRB2 (crumbs cell polarity complex component 2) Homo sapiens
Symbol: CRB2
Name: crumbs cell polarity complex component 2
Description: Exhibits aspartic-type endopeptidase inhibitor activity. Involved in negative regulation of endopeptidase activity. Localizes to the protein-containing complex. Implicated in focal segmental glomerulosclerosis 9.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: crumbs 2, cell polarity complex component; crumbs family member 2; crumbs homolog 2; crumbs-like protein 2; FLJ16786; FLJ38464; FSGS9; RP11-230L22.2; VMCKD
Mus musculus (house mouse) : Crb2 (crumbs family member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Crb2 (crumbs cell polarity complex component 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crb2 (crumbs cell polarity complex component 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CRB2 (crumbs cell polarity complex component 2)
Canis lupus familiaris (dog) : CRB2 (crumbs cell polarity complex component 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crb2 (crumbs cell polarity complex component 2)
Sus scrofa (pig) : CRB2 (crumbs cell polarity complex component 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389123,354,065 - 123,380,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379126,118,448 - 126,141,034 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369125,158,269 - 125,180,853 (+)NCBINCBI36hg18NCBI36
Build 349123,198,002 - 123,215,932NCBI
Celera996,766,676 - 96,789,262 (+)NCBI
Cytogenetic Map9q33.3NCBI
HuRef995,733,274 - 95,755,982 (+)NCBIHuRef
CHM1_19126,267,135 - 126,291,277 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CRB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347869
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.