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Gene: SOX3 (SRY-box transcription factor 3) Homo sapiens
Symbol: SOX3
Name: SRY-box transcription factor 3
CRRD ID: 1347884
Description: Exhibits sequence-specific double-stranded DNA binding activity. Involved in sex determination. Localizes to nucleoplasm. Implicated in X-linked panhypopituitarism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GHDX; MRGH; panhypopituitarism; PHP; PHPX; SOXB; SRY (sex determining region Y)-box 3; SRY box 3; SRY-box 3; transcription factor SOX-3
Mus musculus (house mouse) : Sox3 (SRY (sex determining region Y)-box 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sox3 (SRY-box transcription factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox3 (SRY-box transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX3 (SRY-box transcription factor 3)
Canis lupus familiaris (dog) : SOX3 (SRY-box transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sox3 (SRY-box transcription factor 3)
Sus scrofa (pig) : SOX3 (SRY-box transcription factor 3)
Chlorocebus sabaeus (African green monkey) : SOX3 (SRY-box transcription factor 3)
Heterocephalus glaber (naked mole-rat) : Sox3 (SRY-box transcription factor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX140,502,985 - 140,505,116 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX140,502,985 - 140,505,069 (-)EnsemblGRCh38hg38GRCh38
GRCh38X140,502,985 - 140,505,069 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X139,585,152 - 139,587,225 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X139,412,818 - 139,414,891 (-)NCBINCBI36hg18NCBI36
Build 34X139,310,671 - 139,312,745NCBI
CeleraX139,957,265 - 139,959,338 (-)NCBI
Cytogenetic MapXq27.1NCBI
HuRefX128,852,437 - 128,854,510 (-)NCBIHuRef
CHM1_1X139,496,277 - 139,498,350 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SOX3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347884
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.