Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PCK1 (phosphoenolpyruvate carboxykinase 1) Homo sapiens
Symbol: PCK1
Name: phosphoenolpyruvate carboxykinase 1
CRRD ID: 1347922
Description: Exhibits several functions, including anion binding activity; metal ion binding activity; and phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including cellular response to glucose stimulus; cellular response to insulin stimulus; and gluconeogenesis. Localizes to cytosol and endoplasmic reticulum. Implicated in Alzheimer's disease and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC22652; PCKDC; PEP carboxykinase; PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase; serine-protein kinase PCK1
Mus musculus (house mouse) : Pck1 (phosphoenolpyruvate carboxykinase 1, cytosolic)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pck1 (phosphoenolpyruvate carboxykinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pck1 (phosphoenolpyruvate carboxykinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Canis lupus familiaris (dog) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pck1 (phosphoenolpyruvate carboxykinase 1)
Sus scrofa (pig) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Chlorocebus sabaeus (African green monkey) : PCK1 (phosphoenolpyruvate carboxykinase 1)
Heterocephalus glaber (naked mole-rat) : Pck1 (phosphoenolpyruvate carboxykinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2057,561,080 - 57,568,121 (+)EnsemblGRCh38hg38GRCh38
GRCh382057,561,110 - 57,568,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372056,136,137 - 56,141,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362055,569,543 - 55,574,922 (+)NCBINCBI36hg18NCBI36
Build 342055,569,542 - 55,574,922NCBI
Celera2052,876,507 - 52,881,880 (+)NCBI
Cytogenetic Map20q13.31NCBI
HuRef2052,917,936 - 52,923,310 (+)NCBIHuRef
CHM1_12056,037,177 - 56,042,551 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PCK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347922
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.