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Gene: VWF (von Willebrand factor) Homo sapiens
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Symbol: VWF
Name: von Willebrand factor
Description: Exhibits several functions, including chaperone binding activity; integrin binding activity; and protein homodimerization activity. Involved in cell-substrate adhesion; platelet activation; and protein homooligomerization. Localizes to the Weibel-Palade body; collagen-containing extracellular matrix; and endoplasmic reticulum. Implicated in several diseases, including Behcet's disease; atrial fibrillation; end stage renal failure; essential thrombocythemia; and inherited blood coagulation disease (multiple). Biomarker of several diseases, including end stage renal failure; familial combined hyperlipidemia; obesity; systemic scleroderma; and von Willebrand's disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: coagulation factor VIII VWF; F8VWF; VWD
Orthologs:
Mus musculus (house mouse) : Vwf (Von Willebrand factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vwf (von Willebrand factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vwf (von Willebrand factor)
Pan paniscus (bonobo/pygmy chimpanzee) : VWF (von Willebrand factor)
Canis lupus familiaris (dog) : VWF (von Willebrand factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vwf (von Willebrand factor)
Sus scrofa (pig) : VWF (von Willebrand factor)
Chlorocebus sabaeus (green monkey) : VWF (von Willebrand factor)
Heterocephalus glaber (naked mole-rat) : Vwf (von Willebrand factor)
more info ...
Related Pseudogenes: VWFP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl125,948,874 - 6,124,770 (-)Ensembl
GRCh38125,948,874 - 6,124,675 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,058,040 - 6,233,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,928,301 - 6,104,097 (-)NCBINCBI36hg18NCBI36
Build 34125,928,307 - 6,104,097NCBI
Celera127,677,686 - 7,853,476 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef125,910,003 - 6,085,514 (-)NCBIHuRef
CHM1_1126,057,433 - 6,233,303 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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