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Gene: SPANXD (SPANX family member D) Homo sapiens
Symbol: SPANXD
Name: SPANX family member D
Description: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cancer/testis antigen 11.3; cancer/testis antigen 11.4; cancer/testis antigen family 11, member 4; Cancer/testis-associated protein CTp11; CT11.3; CT11.4; dJ171K16.1; MGC119769; MGC71908; Nuclear-associated protein SPAN-Xc; nuclear-associated protein SPAN-Xd; nuclear-associated protein SPAN-Xe; SPAN-Xd protein; SPAN-Xe protein; SPANX family, member D; SPANX family, member E; SPANX-A2; SPANX-C; SPANX-D; SPANX-E; SPANXA2; SPANXC; SPANXE; SPANXE; Sperm protein associated with the nucleus on the X chromosome C; sperm protein associated with the nucleus on the X chromosome D; sperm protein associated with the nucleus on the X chromosome E; sperm protein associated with the nucleus, X chromosome, family member D; sperm protein associated with the nucleus, X chromosome, family member E
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X141,697,401 - 141,698,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X140,785,568 - 140,786,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X140,613,234 - 140,614,264 (-)NCBINCBI36hg18NCBI36
Build 34X140,511,087 - 140,512,118NCBI
CeleraX141,072,907 - 141,073,938 (-)NCBI
Cytogenetic MapXq27.2NCBI
CHM1_1X140,696,682 - 140,698,020 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPANXD
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347946
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.