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Gene: RNF168 (ring finger protein 168) Homo sapiens
Symbol: RNF168
Name: ring finger protein 168
CRRD ID: 1347950
Description: Exhibits several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including histone H2A ubiquitination; regulation of nucleobase-containing compound metabolic process; and response to ionizing radiation. Localizes to several cellular components, including nucleoplasm; site of double-strand break; and ubiquitin ligase complex. Implicated in RIDDLE syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749; hRNF168; RIDL; ring finger protein 168, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF168
Mus musculus (house mouse) : Rnf168 (ring finger protein 168)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf168 (ring finger protein 168)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf168 (ring finger protein 168)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF168 (ring finger protein 168)
Canis lupus familiaris (dog) : RNF168 (ring finger protein 168)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf168 (ring finger protein 168)
Sus scrofa (pig) : RNF168 (ring finger protein 168)
Chlorocebus sabaeus (African green monkey) : RNF168 (ring finger protein 168)
Heterocephalus glaber (naked mole-rat) : Rnf168 (ring finger protein 168)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3196,468,783 - 196,503,768 (-)EnsemblGRCh38hg38GRCh38
GRCh383196,468,783 - 196,503,768 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,195,654 - 196,230,639 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,683,025 - 197,714,979 (-)NCBINCBI36hg18NCBI36
Build 343197,686,938 - 197,718,892NCBI
Celera3194,777,591 - 194,812,751 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3193,493,420 - 193,527,598 (-)NCBIHuRef
CHM1_13196,167,064 - 196,202,063 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RNF168
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347950
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.