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Gene: RNF168 (ring finger protein 168) Homo sapiens
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Symbol: RNF168
Name: ring finger protein 168
Description: Exhibits several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including histone H2A ubiquitination; regulation of nucleobase-containing compound metabolic process; and response to ionizing radiation. Localizes to several cellular components, including the nucleoplasm; site of double-strand break; and ubiquitin ligase complex. Implicated in RIDDLE syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749; hRNF168; RIDL; ring finger protein 168, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF168
Orthologs:
Mus musculus (house mouse) : Rnf168 (ring finger protein 168)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf168 (ring finger protein 168)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf168 (ring finger protein 168)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF168 (ring finger protein 168)
Canis lupus familiaris (dog) : RNF168 (ring finger protein 168)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf168 (ring finger protein 168)
Sus scrofa (pig) : RNF168 (ring finger protein 168)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,468,783 - 196,503,768 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,195,654 - 196,230,639 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,683,025 - 197,714,979 (-)NCBINCBI36hg18NCBI36
Build 343197,686,938 - 197,718,892NCBI
Celera3194,777,591 - 194,812,751 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3193,493,420 - 193,527,598 (-)NCBIHuRef
CHM1_13196,167,064 - 196,202,063 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on RNF168
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347950
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.