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Gene: RAN (RAN, member RAS oncogene family) Homo sapiens
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Symbol: RAN
Name: RAN, member RAS oncogene family
Description: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: androgen receptor-associated protein 24; ARA24; Gsp1; GTP-binding nuclear protein Ran; GTPase Ran; guanosine triphosphatase Ran; member RAS oncogene family; OK/SW-cl.81; RanGTPase; ras-like protein TC4; ras-related nuclear protein; TC4
Orthologs:
Mus musculus (house mouse) : Ran (RAN, member RAS oncogene family)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ran (RAN, member RAS oncogene family)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ran (RAN, member RAS oncogene family)
Pan paniscus (bonobo/pygmy chimpanzee) : RAN (RAN, member RAS oncogene family)
Canis lupus familiaris (dog) : RAN (RAN, member RAS oncogene family)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ran (RAN, member RAS oncogene family)
Sus scrofa (pig) : RAN (RAN, member RAS oncogene family)
more info ...
Related Pseudogenes: RANP1   RANP2   RANP3   RANP4   RANP5   RANP6   RANP7   RANP8   RANP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812130,871,879 - 130,877,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712131,356,617 - 131,362,220 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612129,922,521 - 129,927,316 (+)NCBINCBI36hg18NCBI36
Build 3412129,881,447 - 129,886,243NCBI
Celera12130,970,022 - 130,974,231 (+)NCBI
Cytogenetic Map12q24.33NCBI
HuRef12128,338,826 - 128,343,035 (+)NCBIHuRef
CHM1_112131,177,300 - 131,182,984 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on RAN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348006
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.