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Gene: HMGA2 (high mobility group AT-hook 2) Homo sapiens
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Symbol: HMGA2
Name: high mobility group AT-hook 2
Description: This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BABL; high mobility group AT-hook protein 2; high mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; HMGA2/KRT121P fusion; HMGI-C; HMGIC; LIPO; STQTL9
Orthologs:
Mus musculus (house mouse) : Hmga2 (high mobility group AT-hook 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hmga2 (high mobility group AT-hook 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmga2 (high mobility group AT-hook 2)
Canis lupus familiaris (dog) : HMGA2 (high mobility group AT-hook 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmga2 (high mobility group AT-hook 2)
Sus scrofa (pig) : HMGA2 (high mobility group AT-hook 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,824,460 - 65,966,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371266,218,240 - 66,360,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,504,507 - 64,646,338 (+)NCBINCBI36hg18NCBI36
Build 341264,504,457 - 64,646,266NCBI
Celera1265,883,845 - 66,025,902 (+)NCBI
Cytogenetic Map12q14.3NCBI
HuRef1263,271,242 - 63,413,086 (+)NCBIHuRef
CHM1_11266,185,507 - 66,327,350 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HMGA2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348013
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.