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Gene: HMGA2 (high mobility group AT-hook 2) Homo sapiens
Symbol: HMGA2
Name: high mobility group AT-hook 2
Description: This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BABL; high mobility group AT-hook protein 2; high mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; HMGA2/KRT121P fusion; HMGI-C; HMGIC; LIPO; STQTL9
Mus musculus (house mouse) : Hmga2 (high mobility group AT-hook 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hmga2 (high mobility group AT-hook 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmga2 (high mobility group AT-hook 2)
Canis lupus familiaris (dog) : HMGA2 (high mobility group AT-hook 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmga2 (high mobility group AT-hook 2)
Sus scrofa (pig) : HMGA2 (high mobility group AT-hook 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381265,824,460 - 65,966,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371266,218,240 - 66,360,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,504,507 - 64,646,338 (+)NCBINCBI36hg18NCBI36
Build 341264,504,457 - 64,646,266NCBI
Celera1265,883,845 - 66,025,902 (+)NCBI
Cytogenetic Map12q14.3NCBI
HuRef1263,271,242 - 63,413,086 (+)NCBIHuRef
CHM1_11266,185,507 - 66,327,350 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HMGA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348013
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.