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Gene: SLC4A10 (solute carrier family 4 member 10) Homo sapiens
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Symbol: SLC4A10
Name: solute carrier family 4 member 10
Description: This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: NBCn2; NCBE; sodium-driven chloride bicarbonate exchanger; solute carrier family 4, sodium bicarbonate cotransporter-like, member 10; solute carrier family 4, sodium bicarbonate transporter, member 10
Orthologs:
Mus musculus (house mouse) : Slc4a10 (solute carrier family 4, sodium bicarbonate cotransporter-like, member 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc4a10 (solute carrier family 4 member 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc4a10 (solute carrier family 4 member 10)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC4A10 (solute carrier family 4 member 10)
Canis lupus familiaris (dog) : SLC4A10 (solute carrier family 4 member 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc4a10 (solute carrier family 4 member 10)
Sus scrofa (pig) : SLC4A10 (solute carrier family 4 member 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382161,620,963 - 161,985,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372162,480,699 - 162,841,786 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,189,091 - 162,550,032 (+)NCBINCBI36hg18NCBI36
Build 342162,306,452 - 162,665,750NCBI
Celera2156,091,092 - 156,452,030 (+)NCBI
Cytogenetic Map2q24.2NCBI
HuRef2154,363,681 - 154,723,673 (+)NCBIHuRef
CHM1_12162,486,707 - 162,847,707 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC4A10
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348028
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.