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Gene: NSUN2 (NOP2/Sun RNA methyltransferase 2) Homo sapiens
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Symbol: NSUN2
Name: NOP2/Sun RNA methyltransferase 2
Description: Exhibits mRNA (cytidine-5-)-methyltransferase activity and tRNA (cytosine-5-)-methyltransferase activity. Involved in mRNA methylation; regulation of mRNA export from nucleus; and tRNA methylation. Localizes to the extracellular exosome; mitochondrion; and nucleolus. Implicated in autosomal recessive non-syndromic intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-methycytoisine methyltransferase; FLJ20303; hTrm4; mental retardation, non-syndromic, autosomal recessive, 5; MISU; mRNA cytosine C(5)-methyltransferase; MRT5; myc-induced SUN domain-containing protein; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family 2; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family member 2; NOP2/Sun RNA methyltransferase family, member 2; RNA cytosine C(5)-methyltransferase NSUN2; SAKI; substrate of AIM1/Aurora kinase B; TRM4; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase; tRNA methyltransferase 4 homolog
Orthologs:
Mus musculus (house mouse) : Nsun2 (NOL1/NOP2/Sun domain family member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nsun2 (NOP2/Sun RNA methyltransferase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nsun2 (NOP2/Sun RNA methyltransferase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NSUN2 (NOP2/Sun RNA methyltransferase 2)
Canis lupus familiaris (dog) : NSUN2 (NOP2/Sun RNA methyltransferase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nsun2 (NOP2/Sun RNA methyltransferase 2)
Sus scrofa (pig) : NSUN2 (NOP2/Sun RNA methyltransferase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl56,599,239 - 6,633,291 (-)Ensembl
GRCh3856,599,239 - 6,633,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3756,599,352 - 6,633,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,652,352 - 6,686,157 (-)NCBINCBI36hg18NCBI36
Build 3456,652,352 - 6,686,157NCBI
Celera56,626,418 - 6,660,533 (-)NCBI
Cytogenetic Map5p15.31NCBI
HuRef56,573,722 - 6,608,099 (-)NCBIHuRef
CHM1_156,599,051 - 6,633,433 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NSUN2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348039
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.