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Gene: BRAP (BRCA1 associated protein) Homo sapiens
Symbol: BRAP
Name: BRCA1 associated protein
Description: Exhibits identical protein binding activity; nuclear localization sequence binding activity; and ubiquitin protein ligase activity. Involved in intracellular signal transduction; negative regulation of signal transduction; and protein ubiquitination. Localizes to cytosol; nuclear membrane; and ubiquitin ligase complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BRAP2; BRCA1-associated protein; galectin-2-binding protein; IMP; impedes mitogenic signal propagation; renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; RNF52
Mus musculus (house mouse) : Brap (BRCA1 associated protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Brap (BRCA1 associated protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Brap (BRCA1 associated protein)
Pan paniscus (bonobo/pygmy chimpanzee) : BRAP (BRCA1 associated protein)
Canis lupus familiaris (dog) : BRAP (BRCA1 associated protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Brap (BRCA1 associated protein)
Sus scrofa (pig) : BRAP (BRCA1 associated protein)
Chlorocebus sabaeus (African green monkey) : BRAP (BRCA1 associated protein)
Heterocephalus glaber (naked mole-rat) : Brap (BRCA1 associated protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: BRAP (Gene ID: 8315) and C6orf89 (Gene ID: 221477) share the BRAP symbol/alias in common. BRAP is a widely used alternative name for chromosome 6 open reading frame 89 (C6orf89), which can be confused with the official symbol for BRCA1-associated protein (BRAP). [05 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl12111,642,146 - 111,685,956 (-)EnsemblGRCh38hg38GRCh38
GRCh3812111,642,146 - 111,686,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712112,079,950 - 112,123,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,566,280 - 110,608,122 (-)NCBINCBI36hg18NCBI36
Build 3412110,544,615 - 110,586,459NCBI
Celera12111,705,482 - 111,749,255 (-)NCBI
Cytogenetic Map12q24.12NCBI
HuRef12109,093,402 - 109,137,289 (-)NCBIHuRef
CHM1_112112,047,902 - 112,091,763 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on BRAP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348068
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.