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Gene: KLF8 (Kruppel like factor 8) Homo sapiens
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Symbol: KLF8
Name: Kruppel like factor 8
Description: This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic krueppel-like factor 3; basic kruppel-like factor 3; BKLF3; DKFZp686O08126; Krueppel-like factor 8; Kruppel-like factor 8; MGC138314; zinc finger protein 741; ZNF741
Orthologs:
Mus musculus (house mouse) : Klf8 (Kruppel-like factor 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Klf8 (Kruppel-like factor 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klf8 (Kruppel like factor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : KLF8 (Kruppel like factor 8)
Canis lupus familiaris (dog) : KLF8 (Kruppel like factor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klf8 (Kruppel like factor 8)
Sus scrofa (pig) : KLF8 (Kruppel like factor 8)
more info ...
Related Pseudogenes: KLF8P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X55,908,123 - 56,291,531 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X56,258,814 - 56,314,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X56,275,632 - 56,328,255 (+)NCBINCBI36hg18NCBI36
Build 34X56,142,352 - 56,194,675NCBI
CeleraX60,097,322 - 60,152,463 (+)NCBI
Cytogenetic MapXp11.21NCBI
HuRefX53,312,220 - 53,367,441 (+)NCBIHuRef
CHM1_1X55,924,532 - 56,308,119 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KLF8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348117
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.