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Gene: KLF8 (Kruppel like factor 8) Homo sapiens
Symbol: KLF8
Name: Kruppel like factor 8
Description: This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic krueppel-like factor 3; basic kruppel-like factor 3; BKLF3; DKFZp686O08126; Krueppel-like factor 8; Kruppel-like factor 8; MGC138314; zinc finger protein 741; ZNF741
Mus musculus (house mouse) : Klf8 (Kruppel-like factor 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Klf8 (Kruppel-like factor 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klf8 (Kruppel like factor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : KLF8 (Kruppel like factor 8)
Canis lupus familiaris (dog) : KLF8 (Kruppel like factor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klf8 (Kruppel like factor 8)
Sus scrofa (pig) : KLF8 (Kruppel like factor 8)
more info ...
Related Pseudogenes: KLF8P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X55,908,123 - 56,291,531 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X56,258,814 - 56,314,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X56,275,632 - 56,328,255 (+)NCBINCBI36hg18NCBI36
Build 34X56,142,352 - 56,194,675NCBI
CeleraX60,097,322 - 60,152,463 (+)NCBI
Cytogenetic MapXp11.21NCBI
HuRefX53,312,220 - 53,367,441 (+)NCBIHuRef
CHM1_1X55,924,532 - 56,308,119 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KLF8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348117
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.