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Gene: IL3RA (interleukin 3 receptor subunit alpha) Homo sapiens
Symbol: IL3RA
Name: interleukin 3 receptor subunit alpha
Description: The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD123; CD123 antigen; hIL-3Ra; IL-3 receptor alpha SP2 isoform; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; IL3R; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; MGC34174
Mus musculus (house mouse) : Il3ra (interleukin 3 receptor, alpha chain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il3ra (interleukin 3 receptor subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il3ra (interleukin 3 receptor subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : IL3RA (interleukin 3 receptor subunit alpha)
Canis lupus familiaris (dog) : IL3RA (interleukin 3 receptor subunit alpha)
Sus scrofa (pig) : IL3RA (interleukin 3 receptor subunit alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X1,336,574 - 1,382,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38Y1,336,574 - 1,382,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X1,455,488 - 1,501,582 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37Y1,405,488 - 1,451,582 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y1,415,509 - 1,461,582 (+)NCBINCBI36hg18NCBI36
Build 36X1,415,509 - 1,461,582 (+)NCBINCBI36hg18NCBI36
Build 34Y1,499,187 - 1,545,408NCBI
CeleraX5,763,883 - 5,782,916 (+)NCBI
Cytogenetic MapXp22.33 and Yp11.2NCBI
CHM1_1X1,486,100 - 1,532,170 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL3RA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348134
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.