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Gene: EDA (ectodysplasin A) Homo sapiens
Symbol: EDA
Name: ectodysplasin A
Description: The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ECTD1; ectodermal dysplasia protein; ectodysplasin-A; ED1; ED1-A1; ED1-A2; EDA-A1; EDA-A2; EDA1; EDA2; HED; HED1; ODT1; oligodontia 1; STHAGX1; TNLG7C; tumor necrosis factor ligand 7C; X-linked anhidroitic ectodermal dysplasia protein; XHED; XLHED
Mus musculus (house mouse) : Eda (ectodysplasin-A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Eda (ectodysplasin-A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eda (ectodysplasin A)
Pan paniscus (bonobo/pygmy chimpanzee) : EDA (ectodysplasin A)
Canis lupus familiaris (dog) : EDA (ectodysplasin A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101956136 (ectodysplasin-A)
Sus scrofa (pig) : EDA (ectodysplasin A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X69,616,067 - 70,039,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X68,835,911 - 69,259,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X68,752,636 - 69,176,047 (+)NCBINCBI36hg18NCBI36
Build 34X68,618,931 - 69,042,340NCBI
CeleraX69,189,229 - 69,612,705 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX62,655,756 - 63,080,124 (+)NCBIHuRef
CHM1_1X68,729,282 - 69,152,930 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EDA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348155
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.