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Gene: EDA (ectodysplasin A) Homo sapiens
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Symbol: EDA
Name: ectodysplasin A
Description: The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ECTD1; ectodermal dysplasia protein; ectodysplasin-A; ED1; ED1-A1; ED1-A2; EDA-A1; EDA-A2; EDA1; EDA2; HED; HED1; ODT1; oligodontia 1; STHAGX1; TNLG7C; tumor necrosis factor ligand 7C; X-linked anhidroitic ectodermal dysplasia protein; XHED; XLHED
Orthologs:
Mus musculus (house mouse) : Eda (ectodysplasin-A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Eda (ectodysplasin-A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eda (ectodysplasin A)
Pan paniscus (bonobo/pygmy chimpanzee) : EDA (ectodysplasin A)
Canis lupus familiaris (dog) : EDA (ectodysplasin A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101956136 (ectodysplasin-A)
Sus scrofa (pig) : EDA (ectodysplasin A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X69,616,067 - 70,039,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X68,835,911 - 69,259,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X68,752,636 - 69,176,047 (+)NCBINCBI36hg18NCBI36
Build 34X68,618,931 - 69,042,340NCBI
CeleraX69,189,229 - 69,612,705 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX62,655,756 - 63,080,124 (+)NCBIHuRef
CHM1_1X68,729,282 - 69,152,930 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on EDA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348155
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.