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Gene: DLD (dihydrolipoamide dehydrogenase) Homo sapiens
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Symbol: DLD
Name: dihydrolipoamide dehydrogenase
Description: Exhibits dihydrolipoyl dehydrogenase activity. Contributes to pyruvate dehydrogenase (NAD+) activity. Involved in histone succinylation. Localizes to several cellular components, including the nucleoplasm; oxoglutarate dehydrogenase complex; and pyruvate dehydrogenase complex. Implicated in maple syrup urine disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: diaphorase; dihydrolipoyl dehydrogenase, mitochondrial; DLDD; DLDH; E3; E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex; GCSL; glycine cleavage system L protein; glycine cleavage system protein L; LAD; lipoamide dehydrogenase; lipoamide reductase; lipoyl dehydrogenase; PHE3
Orthologs:
Mus musculus (house mouse) : Dld (dihydrolipoamide dehydrogenase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dld (dihydrolipoamide dehydrogenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dld (dihydrolipoamide dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLD (dihydrolipoamide dehydrogenase)
Canis lupus familiaris (dog) : DLD (dihydrolipoamide dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dld (dihydrolipoamide dehydrogenase)
Sus scrofa (pig) : DLD (dihydrolipoamide dehydrogenase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387107,891,107 - 107,921,198 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377107,531,586 - 107,561,643 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367107,318,822 - 107,348,879 (+)NCBINCBI36hg18NCBI36
Build 347107,125,561 - 107,154,360NCBI
Celera7102,338,571 - 102,368,626 (+)NCBI
Cytogenetic Map7q31.1NCBI
HuRef7101,894,030 - 101,924,084 (+)NCBIHuRef
CHM1_17107,465,273 - 107,495,360 (+)NCBICHM1_1
CRA_TCAGchr7v27106,892,712 - 106,922,768 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DLD
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348290
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.