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Gene: ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1) Homo sapiens
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Symbol: ARFGEF1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Description: Exhibits guanyl-nucleotide exchange factor activity; myosin binding activity; and protein kinase A regulatory subunit binding activity. Involved in several processes, including negative regulation of GTPase activity; negative regulation of actin filament polymerization; and positive regulation of protein glycosylation in Golgi. Localizes to several cellular components, including the Golgi membrane; nucleus; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); ARFGEP1; BIG1; brefeldin A-inhibited GEP 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; D730028O18Rik; DKFZP434L057; P200; p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38867,174,298 - 67,343,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37868,085,746 - 68,255,912 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36868,272,451 - 68,418,466 (-)NCBINCBI36hg18NCBI36
Build 34868,272,450 - 68,418,466NCBI
Celera864,103,297 - 64,249,319 (-)NCBI
Cytogenetic Map8q13.2NCBI
HuRef863,601,813 - 63,748,371 (-)NCBIHuRef
CHM1_1868,165,896 - 68,311,968 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ARFGEF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348298
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.