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Gene: ACTA2 (actin alpha 2, smooth muscle) Homo sapiens
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Symbol: ACTA2
Name: actin alpha 2, smooth muscle
Description: Predicted to have protein kinase binding activity. Involved in glomerular mesangial cell development and response to virus. Localizes to the cytoplasm and protein-containing complex. Implicated in Moyamoya disease and thoracic aortic aneurysm. Biomarker of lymphedema.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT6; actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; ACTSA; alpha 2 actin; alpha-actin-2; alpha-cardiac actin; cell growth-inhibiting gene 46 protein; growth-inhibiting gene 46; MYMY5
Orthologs:
Mus musculus (house mouse) : Acta2 (actin, alpha 2, smooth muscle, aorta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acta2 (actin alpha 2, smooth muscle)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acta2 (actin alpha 2, smooth muscle)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTA2 (actin alpha 2, smooth muscle)
Canis lupus familiaris (dog) : ACTA2 (actin alpha 2, smooth muscle)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acta2 (actin alpha 2, smooth muscle)
Sus scrofa (pig) : ACTA2 (actin alpha 2, smooth muscle)
Chlorocebus sabaeus (African green monkey) : ACTA2 (actin alpha 2, smooth muscle)
Heterocephalus glaber (naked mole-rat) : Acta2 (actin alpha 2, smooth muscle)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1088,935,074 - 88,991,339 (-)Ensembl
GRCh381088,935,074 - 88,991,397 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371090,694,831 - 90,751,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,684,811 - 90,702,491 (-)NCBINCBI36hg18NCBI36
Build 341090,684,810 - 90,702,491NCBI
Celera1084,441,676 - 84,497,934 (-)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1084,329,337 - 84,385,614 (-)NCBIHuRef
CHM1_11090,976,918 - 91,033,214 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ACTA2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348351
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.