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Gene: METTL3 (methyltransferase like 3) Homo sapiens
Symbol: METTL3
Name: methyltransferase like 3
Description: Exhibits several functions, including S-adenosyl-L-methionine binding activity; mRNA (N6-adenosine)-methyltransferase activity; and protein heterodimerization activity. Involved in several processes, including RNA metabolic process; negative regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Localizes to the RNA N6-methyladenosine methyltransferase complex and nuclear speck.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; IME4; M6A; methyltransferase-like protein 3; MGC4336; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase catalytic subunit; Spo8
Mus musculus (house mouse) : Mettl3 (methyltransferase like 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mettl3 (methyltransferase-like 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mettl3 (methyltransferase like 3)
Pan paniscus (bonobo/pygmy chimpanzee) : METTL3 (methyltransferase like 3)
Canis lupus familiaris (dog) : METTL3 (methyltransferase like 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mettl3 (methyltransferase like 3)
Sus scrofa (pig) : METTL3 (methyltransferase like 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1421,498,133 - 21,511,342 (-)Ensembl
GRCh381421,498,138 - 21,511,340 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371421,966,282 - 21,979,517 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,036,122 - 21,049,297 (-)NCBINCBI36hg18NCBI36
Build 341421,036,128 - 21,049,291NCBI
Celera141,829,623 - 1,842,799 (-)NCBI
Cytogenetic Map14q11.2NCBI
HuRef142,084,139 - 2,097,311 (-)NCBIHuRef
CHM1_11421,967,740 - 21,980,983 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on METTL3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348378
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.