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Gene: LRRC14 (leucine rich repeat containing 14) Homo sapiens
Symbol: LRRC14
Name: leucine rich repeat containing 14
Description: Exhibits kinase binding activity. Involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of toll-like receptor signaling pathway. Localizes to cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: KIAA0014; leucine-rich repeat-containing protein 14; LRRC14A
Mus musculus (house mouse) : Lrrc14 (leucine rich repeat containing 14)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrrc14 (leucine rich repeat containing 14)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrc14 (leucine rich repeat containing 14)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRC14 (leucine rich repeat containing 14)
Canis lupus familiaris (dog) : LRRC14 (leucine rich repeat containing 14)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrc14 (leucine rich repeat containing 14)
Sus scrofa (pig) : LRRC14 (leucine rich repeat containing 14)
Chlorocebus sabaeus (African green monkey) : LRRC14 (leucine rich repeat containing 14)
Heterocephalus glaber (naked mole-rat) : Lrrc14 (leucine rich repeat containing 14)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8144,517,992 - 144,525,172 (+)EnsemblGRCh38hg38GRCh38
GRCh388144,517,965 - 144,525,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,743,349 - 145,750,562 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,714,199 - 145,721,365 (+)NCBINCBI36hg18NCBI36
Build 348145,714,198 - 145,721,365NCBI
Celera8141,919,071 - 141,926,237 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,856,834 - 140,864,047 (+)NCBIHuRef
CHM1_18145,781,538 - 145,788,752 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on LRRC14
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348401
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.