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Gene: DCLRE1C (DNA cross-link repair 1C) Homo sapiens
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Symbol: DCLRE1C
Name: DNA cross-link repair 1C
Description: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A-SCID; DCLREC1C; DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae); DNA cross-link repair 1C protein; FLJ11360; FLJ36438; hSNM1C; protein artemis; PSO2 homolog; RS-SCID; SCIDA; severe combined immunodeficiency, type a (Athabascan); SNM1 homolog C; SNM1-like protein; SNM1C
Orthologs:
Mus musculus (house mouse) : Dclre1c (DNA cross-link repair 1C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dclre1c (DNA cross-link repair 1C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dclre1c (DNA cross-link repair 1C)
Pan paniscus (bonobo/pygmy chimpanzee) : DCLRE1C (DNA cross-link repair 1C)
Canis lupus familiaris (dog) : DCLRE1C (DNA cross-link repair 1C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dclre1c (DNA cross-link repair 1C)
Sus scrofa (pig) : DCLRE1C (DNA cross-link repair 1C)
more info ...
Related Pseudogenes: DCLRE1CP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381014,897,564 - 14,954,432 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371014,948,870 - 14,996,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361014,988,876 - 15,036,100 (-)NCBINCBI36hg18NCBI36
Build 341014,989,883 - 15,036,100NCBI
Celera1014,876,909 - 14,924,986 (-)NCBI
Cytogenetic Map10p13NCBI
HuRef1014,859,351 - 14,906,283 (-)NCBIHuRef
CHM1_11014,946,730 - 14,996,567 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DCLRE1C
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348428
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.