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Gene: GCSH (glycine cleavage system protein H) Homo sapiens
Symbol: GCSH
Name: glycine cleavage system protein H
Description: Predicted to have aminomethyltransferase activity. Involved in protein lipoylation. Predicted to localize to the mitochondrial matrix. Implicated in glycine encephalopathy. Biomarker of amino acid metabolic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GCE; glycine cleavage system H protein, mitochondrial; glycine cleavage system protein H (aminomethyl carrier); lipoic acid-containing protein; mitochondrial glycine cleavage system H-protein; NKH
Mus musculus (house mouse) : Gcsh (glycine cleavage system protein H (aminomethyl carrier))  MGI  Alliance
Rattus norvegicus (Norway rat) : Gcsh (glycine cleavage system protein H)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gcsh (glycine cleavage system protein H)
Pan paniscus (bonobo/pygmy chimpanzee) : GCSH (glycine cleavage system protein H)
Canis lupus familiaris (dog) : GCSH (glycine cleavage system protein H)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gcsh (glycine cleavage system protein H)
Sus scrofa (pig) : GCSH (glycine cleavage system protein H)
more info ...
Related Pseudogenes: GCSHP1   GCSHP2   GCSHP3   GCSHP4   GCSHP5  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381681,081,945 - 81,096,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371681,115,552 - 81,129,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361679,673,430 - 79,687,481 (-)NCBINCBI36hg18NCBI36
Build 341679,673,429 - 79,687,481NCBI
Celera1665,413,951 - 65,428,027 (-)NCBI
Cytogenetic Map16q23.2NCBI
HuRef1666,872,363 - 66,886,447 (-)NCBIHuRef
CHM1_11682,526,910 - 82,541,365 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GCSH
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348453
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.