Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: IRAK1 (interleukin 1 receptor associated kinase 1) Homo sapiens
Symbol: IRAK1
Name: interleukin 1 receptor associated kinase 1
CRRD ID: 1348457
Description: Exhibits protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of DNA-binding transcription factor activity; and regulation of signal transduction. Localizes to cytosol; nucleoplasm; and protein-containing complex. Implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Biomarker of psoriasis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: interleukin-1 receptor-associated kinase 1; IRAK; IRAK-1; pelle; Pelle homolog
Mus musculus (house mouse) : Irak1 (interleukin-1 receptor-associated kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irak1 (interleukin-1 receptor-associated kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irak1 (interleukin 1 receptor associated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRAK1 (interleukin 1 receptor associated kinase 1)
Canis lupus familiaris (dog) : IRAK1 (interleukin 1 receptor associated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irak1 (interleukin 1 receptor associated kinase 1)
Sus scrofa (pig) : IRAK1 (interleukin 1 receptor associated kinase 1)
Chlorocebus sabaeus (African green monkey) : IRAK1 (interleukin 1 receptor associated kinase 1)
Heterocephalus glaber (naked mole-rat) : Irak1 (interleukin 1 receptor associated kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX154,010,506 - 154,019,902 (-)EnsemblGRCh38hg38GRCh38
GRCh38X154,010,507 - 154,019,984 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,275,957 - 153,285,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,929,151 - 152,938,536 (-)NCBINCBI36hg18NCBI36
Build 34X152,796,808 - 152,806,189NCBI
CeleraX153,509,662 - 153,519,047 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,927,208 - 141,942,770 (-)NCBIHuRef
CHM1_1X153,150,366 - 153,159,748 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IRAK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348457
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.