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Gene: IRAK1 (interleukin 1 receptor associated kinase 1) Homo sapiens
Symbol: IRAK1
Name: interleukin 1 receptor associated kinase 1
Description: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: interleukin-1 receptor-associated kinase 1; IRAK; IRAK-1; pelle; Pelle homolog
Mus musculus (house mouse) : Irak1 (interleukin-1 receptor-associated kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irak1 (interleukin-1 receptor-associated kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irak1 (interleukin 1 receptor associated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRAK1 (interleukin 1 receptor associated kinase 1)
Canis lupus familiaris (dog) : IRAK1 (interleukin 1 receptor associated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irak1 (interleukin 1 receptor associated kinase 1)
Sus scrofa (pig) : IRAK1 (interleukin 1 receptor associated kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X154,010,506 - 154,019,984 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,275,957 - 153,285,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,929,151 - 152,938,536 (-)NCBINCBI36hg18NCBI36
Build 34X152,796,808 - 152,806,189NCBI
CeleraX153,509,662 - 153,519,047 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,927,208 - 141,942,770 (-)NCBIHuRef
CHM1_1X153,150,366 - 153,159,748 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IRAK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348457
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.