Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PARN (poly(A)-specific ribonuclease) Homo sapiens
Analyze
Symbol: PARN
Name: poly(A)-specific ribonuclease
Description: Exhibits cation binding activity; poly(A)-specific ribonuclease activity; and protein kinase binding activity. Involved in several processes, including RNA metabolic process; positive regulation of DNA biosynthetic process; and telomerase RNA stabilization. Localizes to the nuclear speck and nucleolus. Implicated in autosomal recessive dyskeratosis congenita 6.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DAN; deadenylating nuclease; deadenylation nuclease; DKCB6; PFBMFT4; poly(A)-specific ribonuclease (deadenylation nuclease); poly(A)-specific ribonuclease PARN; polyadenylate-specific ribonuclease
Orthologs:
Mus musculus (house mouse) : Parn (poly(A)-specific ribonuclease (deadenylation nuclease))  MGI  Alliance
Rattus norvegicus (Norway rat) : Parn (poly(A)-specific ribonuclease)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Parn (poly(A)-specific ribonuclease)
Pan paniscus (bonobo/pygmy chimpanzee) : PARN (poly(A)-specific ribonuclease)
Canis lupus familiaris (dog) : PARN (poly(A)-specific ribonuclease)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Parn (poly(A)-specific ribonuclease)
Sus scrofa (pig) : PARN (poly(A)-specific ribonuclease)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,435,701 - 14,630,286 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371614,529,557 - 14,724,128 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,437,060 - 14,631,540 (-)NCBINCBI36hg18NCBI36
Build 341614,437,059 - 14,631,540NCBI
Celera1614,706,337 - 14,900,899 (-)NCBI
Cytogenetic Map16p13.12NCBI
HuRef1614,448,361 - 14,642,982 (-)NCBIHuRef
CHM1_11614,529,504 - 14,723,956 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PARN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348471
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.