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Gene: GRK5 (G protein-coupled receptor kinase 5) Homo sapiens
Symbol: GRK5
Name: G protein-coupled receptor kinase 5
Description: Exhibits beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process; protein autophosphorylation; and tachykinin receptor signaling pathway. Localizes to cytosol; nucleus; and plasma membrane. Biomarker of Parkinson's disease and congestive heart failure.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ39780; FP2025; g protein-coupled receptor kinase GRK5; GPRK5
Mus musculus (house mouse) : Grk5 (G protein-coupled receptor kinase 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grk5 (G protein-coupled receptor kinase 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk5 (G protein-coupled receptor kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK5 (G protein-coupled receptor kinase 5)
Canis lupus familiaris (dog) : GRK5 (G protein-coupled receptor kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk5 (G protein-coupled receptor kinase 5)
Sus scrofa (pig) : GRK5 (G protein-coupled receptor kinase 5)
Chlorocebus sabaeus (African green monkey) : GRK5 (G protein-coupled receptor kinase 5)
Heterocephalus glaber (naked mole-rat) : Grk5 (G protein-coupled receptor kinase 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10119,207,571 - 119,459,745 (+)EnsemblGRCh38hg38GRCh38
GRCh3810119,207,571 - 119,459,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710120,967,197 - 121,215,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,957,187 - 121,205,121 (+)NCBINCBI36hg18NCBI36
Build 3410120,957,186 - 121,205,120NCBI
Celera10114,696,799 - 114,943,133 (+)NCBI
Cytogenetic Map10q26.11NCBI
HuRef10114,596,405 - 114,842,644 (+)NCBIHuRef
CHM1_110121,251,583 - 121,499,541 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GRK5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348499
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.