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Gene: WDR45 (WD repeat domain 45) Homo sapiens
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Symbol: WDR45
Name: WD repeat domain 45
Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: JM5; NBIA4; NBIA5; neurodegeneration with brain iron accumulation 4; neurodegeneration with brain iron accumulation 5; WD repeat domain phosphoinositide-interacting protein 4; WD repeat domain, X-linked 1; WD repeat-containing protein 45; WD45 repeat protein interacting with phosphoinositides 4; WDRX1; WIPI-4; WIPI4
Orthologs:
Mus musculus (house mouse) : Wdr45 (WD repeat domain 45)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wdr45 (WD repeat domain 45)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wdr45 (WD repeat domain 45)
Pan paniscus (bonobo/pygmy chimpanzee) : WDR45 (WD repeat domain 45)
Canis lupus familiaris (dog) : WDR45 (WD repeat domain 45)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wdr45 (WD repeat domain 45)
Sus scrofa (pig) : WDR45 (WD repeat domain 45)
more info ...
Related Pseudogenes: WDR45P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X49,074,433 - 49,101,121 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X48,932,092 - 48,958,059 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,819,036 - 48,845,003 (-)NCBINCBI36hg18NCBI36
Build 34X48,688,548 - 48,714,308NCBI
CeleraX52,706,432 - 52,732,399 (+)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,588,725 - 46,614,834 (-)NCBIHuRef
CHM1_1X48,963,413 - 48,989,776 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on WDR45
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348509
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.