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Gene: WDR45 (WD repeat domain 45) Homo sapiens
Symbol: WDR45
Name: WD repeat domain 45
Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: JM5; NBIA4; NBIA5; neurodegeneration with brain iron accumulation 4; neurodegeneration with brain iron accumulation 5; WD repeat domain phosphoinositide-interacting protein 4; WD repeat domain, X-linked 1; WD repeat-containing protein 45; WD45 repeat protein interacting with phosphoinositides 4; WDRX1; WIPI-4; WIPI4
Mus musculus (house mouse) : Wdr45 (WD repeat domain 45)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wdr45 (WD repeat domain 45)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wdr45 (WD repeat domain 45)
Pan paniscus (bonobo/pygmy chimpanzee) : WDR45 (WD repeat domain 45)
Canis lupus familiaris (dog) : WDR45 (WD repeat domain 45)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wdr45 (WD repeat domain 45)
Sus scrofa (pig) : WDR45 (WD repeat domain 45)
more info ...
Related Pseudogenes: WDR45P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X49,074,433 - 49,101,121 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X48,932,092 - 48,958,059 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,819,036 - 48,845,003 (-)NCBINCBI36hg18NCBI36
Build 34X48,688,548 - 48,714,308NCBI
CeleraX52,706,432 - 52,732,399 (+)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,588,725 - 46,614,834 (-)NCBIHuRef
CHM1_1X48,963,413 - 48,989,776 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on WDR45
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348509
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.