Gene: CDK8 (cyclin dependent kinase 8) Homo sapiens
Analyze
Symbol:
CDK8
Name:
cyclin dependent kinase 8
Description:
Predicted to have RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Localizes to the mediator complex and nucleolus.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
CDK8 protein kinase; cell division protein kinase 8; cyclin-dependent kinase 8; K35; mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; protein kinase K35
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Cdk8 (cyclin-dependent kinase 8) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Cdk8 (cyclin-dependent kinase 8) HGNC
EggNOG, Ensembl, HomoloGene, NCBI, OMA, Panther
Chinchilla lanigera (long-tailed chinchilla):
Cdk8 (cyclin dependent kinase 8) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
CDK8 (cyclin dependent kinase 8) NCBI
Ortholog
Canis lupus familiaris (dog):
CDK8 (cyclin dependent kinase 8) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cdk8 (cyclin dependent kinase 8) NCBI
Ortholog
Sus scrofa (pig):
CDK8 (cyclin dependent kinase 8) HGNC
EggNOG, Ensembl, NCBI, OMA, OrthoDB, Treefam
Other homologs 2
Canis lupus familiaris (dog):
CDK19 (cyclin dependent kinase 19) HGNC
EggNOG, OrthoDB, OrthoMCL
Rattus norvegicus (Norway rat):
Cdk19 (cyclin-dependent kinase 19) HGNC
OrthoDB, OrthoMCL
Mus musculus (house mouse):
Cdk19 (cyclin-dependent kinase 19) HGNC
OrthoDB, OrthoMCL
Sus scrofa (pig):
CDK19 (cyclin dependent kinase 19) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cdk8 (cyclin-dependent kinase 8)
Alliance
DIOPT (HGNC, OrthoFinder)
Mus musculus (house mouse):
Cdk8 (cyclin-dependent kinase 8)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
cdk8 (cyclin-dependent kinase 8)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
Cdk8
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
SSN3
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
cdk-8
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
CDK8P1
CDK8P2
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 13 26,254,125 - 26,405,238 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 13 26,828,262 - 26,979,375 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 13 25,726,756 - 25,876,569 (+) NCBI NCBI36 hg18 NCBI36 Build 34 13 25,726,755 - 25,876,569 NCBI Celera 13 7,896,857 - 8,046,682 (+) NCBI Cytogenetic Map 13 q12.13 NCBI HuRef 13 7,646,374 - 7,796,038 (+) NCBI HuRef CHM1_1 13 26,796,281 - 26,947,427 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions ISO RGD:1560888 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CDK8 mRNA] CTD PMID:31150632 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1622878 6480464 Tetrachlorodibenzodioxin affects the expression of CDK8 mRNA CTD PMID:21570461 2-hydroxypropanoic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of CDK8 mRNA CTD PMID:30851411 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1622878 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of CDK8 mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine increases methylation ISO RGD:1622878 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of CDK8 promoter CTD PMID:26251327 5-aza-2'-deoxycytidine decreases methylation ISO RGD:1622878 6480464 Decitabine results in decreased methylation of CDK8 gene CTD PMID:27923600 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CDK8 mRNA CTD PMID:27153756 aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of CDK8 gene CTD PMID:27153756 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of CDK8 mRNA CTD PMID:15498508 Aroclor 1254 decreases expression ISO RGD:1622878 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CDK8 mRNA CTD PMID:23650126 benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of CDK8 intron CTD PMID:30157460 benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:19150397 , PMID:20382639 benzo[e]pyrene decreases methylation EXP 6480464 benzo(e)pyrene results in decreased methylation of CDK8 intron CTD PMID:30157460 bisphenol A multiple interactions ISO RGD:1560888 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of CDK8 mRNA CTD PMID:26496021 bisphenol A increases expression ISO RGD:1560888 6480464 bisphenol A results in increased expression of CDK8 mRNA CTD PMID:25181051 carbon nanotube decreases expression ISO RGD:1622878 6480464 Nanotubes, Carbon analog results in decreased expression of CDK8 mRNA, Nanotubes, Carbon results in decreased expression of CDK8 mRNA CTD PMID:25554681 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon results in decreased expression of CDK8 mRNA CTD PMID:15585362 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of CDK8 mRNA CTD PMID:23634900 carmustine decreases expression EXP 6480464 Carmustine results in decreased expression of CDK8 mRNA CTD PMID:15980968 clofibrate decreases expression ISO RGD:1622878 6480464 Clofibrate results in decreased expression of CDK8 mRNA CTD PMID:17585979 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of CDK8 mRNA CTD PMID:19376846 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of CDK8 mRNA CTD PMID:29803840 flutamide increases expression ISO RGD:1560888 6480464 Flutamide results in increased expression of CDK8 mRNA CTD PMID:24136188 genistein increases expression EXP 6480464 Genistein results in increased expression of CDK8 mRNA CTD PMID:15378649 metformin multiple interactions EXP 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CDK8 mRNA CTD PMID:29309887 methapyrilene decreases methylation EXP 6480464 Methapyrilene results in decreased methylation of CDK8 intron CTD PMID:30157460 oxaliplatin decreases expression ISO RGD:1560888 6480464 oxaliplatin results in decreased expression of CDK8 mRNA CTD PMID:25729387 oxaliplatin multiple interactions ISO RGD:1560888 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CDK8 mRNA CTD PMID:25729387 paclitaxel multiple interactions EXP 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CDK8 mRNA CTD PMID:29309887 paraquat decreases expression ISO RGD:1622878 6480464 Paraquat results in decreased expression of CDK8 mRNA CTD PMID:21371552 phenylmercury acetate decreases expression EXP 6480464 Phenylmercuric Acetate results in decreased expression of CDK8 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK8 mRNA CTD PMID:27188386 pinosylvin decreases expression EXP 6480464 pinosylvin results in decreased expression of CDK8 mRNA CTD PMID:23333577 progesterone increases expression EXP 6480464 Progesterone results in increased expression of CDK8 mRNA CTD PMID:16888808 quercetin increases expression EXP 6480464 Quercetin results in increased expression of CDK8 mRNA CTD PMID:14715546 rac-lactic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of CDK8 mRNA CTD PMID:30851411 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of CDK8 mRNA CTD PMID:18586690 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 tamibarotene affects expression EXP 6480464 tamibarotene affects the expression of CDK8 mRNA CTD PMID:15498508 tanespimycin decreases expression EXP 6480464 tanespimycin results in decreased expression of CDK8 protein CTD PMID:17157164 testosterone multiple interactions ISO RGD:1560888 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of CDK8 mRNA CTD PMID:26496021 tetrachloromethane increases expression ISO RGD:1560888 6480464 Carbon Tetrachloride results in increased expression of CDK8 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:1560888 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CDK8 mRNA] CTD PMID:31150632 thioacetamide increases expression ISO RGD:1560888 6480464 Thioacetamide results in increased expression of CDK8 mRNA CTD PMID:23411599 titanium dioxide increases expression ISO RGD:1622878 6480464 titanium dioxide results in increased expression of CDK8 mRNA CTD PMID:23557971 topotecan multiple interactions ISO RGD:1560888 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CDK8 mRNA CTD PMID:25729387 trans-pinosylvin decreases expression EXP 6480464 pinosylvin results in decreased expression of CDK8 mRNA CTD PMID:23333577 trichostatin A decreases expression EXP 6480464 trichostatin A results in decreased expression of CDK8 mRNA CTD PMID:26272509 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK8 mRNA CTD PMID:27188386 urethane increases expression EXP 6480464 Urethane results in increased expression of CDK8 mRNA CTD PMID:28818685 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of CDK8 mRNA CTD PMID:23179753 , PMID:28001369 vanadium atom decreases expression EXP 6480464 Vanadium results in decreased expression of CDK8 mRNA CTD PMID:19000753 vanadium(0) decreases expression EXP 6480464 Vanadium results in decreased expression of CDK8 mRNA CTD PMID:19000753 
Gene-Chemical Interaction Annotations
