Gene: DCX (doublecortin) Homo sapiens
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Symbol: DCX
Name: doublecortin
Description: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DBCN; DC; doublecortex; doublin; FLJ51296; lis-X; lissencephalin-X; LISX; neuronal migration protein doublecortin; SCLH; XLIS
Orthologs:
Mus musculus (house mouse) : Dcx (doublecortin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dcx (doublecortin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dcx (doublecortin)
Pan paniscus (bonobo/pygmy chimpanzee) : DCX (doublecortin)
Canis lupus familiaris (dog) : DCX (doublecortin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dcx (doublecortin)
Sus scrofa (pig) : DCX (doublecortin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X111,293,779 - 111,412,232 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X110,537,007 - 110,655,460 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,423,663 - 110,542,062 (-)NCBINCBI36hg18NCBI36
Build 34X110,343,151 - 110,461,551NCBI
CeleraX111,016,623 - 111,134,992 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX100,159,414 - 100,278,099 (-)NCBIHuRef
CHM1_1X110,448,522 - 110,566,950 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DCX
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348637
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-05-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.