Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CDKN2B (cyclin dependent kinase inhibitor 2B) Homo sapiens
Symbol: CDKN2B
Name: cyclin dependent kinase inhibitor 2B
Description: Exhibits cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in several processes, including negative regulation of cell cycle; positive regulation of transforming growth factor beta receptor signaling pathway; and regulation of phosphorylation. Localizes to the cytoplasm and nucleus. Implicated in carcinoma (multiple); erythema infectiosum; hematologic cancer (multiple); open-angle glaucoma; and urinary bladder cancer. Biomarker of acute myeloid leukemia; carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDK inhibitory protein; CDK4B inhibitor; CDK4I; cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; INK4B; MTS-2; MTS2; multiple tumor suppressor 2; p14-INK4b; p14_CDK inhibitor; p14_INK4B; P15; p15 CDK inhibitor; p15-INK4b; p15_INK4B; p15INK4b; TP15
Mus musculus (house mouse) : Cdkn2b (cyclin dependent kinase inhibitor 2B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdkn2b (cyclin-dependent kinase inhibitor 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn2b (cyclin dependent kinase inhibitor 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN2B (cyclin dependent kinase inhibitor 2B)
Canis lupus familiaris (dog) : CDKN2B (cyclin dependent kinase inhibitor 2B)
Sus scrofa (pig) : CDKN2B (cyclin dependent kinase inhibitor 2B)
Chlorocebus sabaeus (green monkey) : CDKN2B (cyclin dependent kinase inhibitor 2B)
Heterocephalus glaber (naked mole-rat) : Cdkn2b (cyclin dependent kinase inhibitor 2B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl922,002,903 - 22,009,305 (-)Ensembl
GRCh38922,002,903 - 22,009,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37922,002,902 - 22,009,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,992,902 - 21,999,312 (-)NCBINCBI36hg18NCBI36
Build 34921,992,902 - 21,999,312NCBI
Celera921,941,270 - 21,947,682 (-)NCBI
Cytogenetic Map9p21.3NCBI
HuRef921,966,171 - 21,972,582 (-)NCBIHuRef
CHM1_1922,002,731 - 22,009,141 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDKN2B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348731
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.