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Gene: LRRFIP1 (LRR binding FLII interacting protein 1) Homo sapiens
Symbol: LRRFIP1
Name: LRR binding FLII interacting protein 1
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Localizes to the cytosol and plasma membrane; INTERACTS WITH (-)-demecolcine; (-)-epigallocatechin 3-gallate; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLAP-1; FLAP1; FLIIAP1; GC-binding factor 2; GCF-2; GCF2; HUFI-1; leucine rich repeat (in FLII) interacting protein 1; leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; MGC10947; MGC119738; MGC119739; NEDD8-conjugating enzyme; TAR RNA-interacting protein; transcription factor 9-like; TRIP
Mus musculus (house mouse) : Lrrfip1 (leucine rich repeat (in FLII) interacting protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrrfip1 (LRR binding FLII interacting protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrfip1 (LRR binding FLII interacting protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRFIP1 (LRR binding FLII interacting protein 1)
Canis lupus familiaris (dog) : LRRFIP1 (LRR binding FLII interacting protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrfip1 (LRR binding FLII interacting protein 1)
Sus scrofa (pig) : LRRFIP1 (LRR binding FLII interacting protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2237,627,587 - 237,813,682 (+)Ensembl
GRCh382237,627,576 - 237,781,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372238,536,224 - 238,690,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,265,668 - 238,338,645 (+)NCBINCBI36hg18NCBI36
Build 342238,382,928 - 238,455,906NCBI
Celera2232,249,255 - 232,403,327 (+)NCBI
Cytogenetic Map2q37.3NCBI
HuRef2230,392,463 - 230,481,948 (+)NCBIHuRef
CHM1_12238,541,235 - 238,696,081 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LRRFIP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348771
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.