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Gene: DEFB4A (defensin beta 4A) Homo sapiens
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Symbol: DEFB4A
Name: defensin beta 4A
Description: Exhibits CCR6 chemokine receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to bacterium; and killing of cells of other organism. Localizes to extracellular space. Biomarker of common cold; cystic fibrosis; and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BD-2; beta defensin 2; beta defensin-2; beta-defensin 2; beta-defensin 4A; DEFB-2; DEFB102; DEFB2; DEFB4; DEFB4B; defensin, beta 2; defensin, beta 4; defensin, beta 4A; HBD-2; SAP1; skin-antimicrobial peptide 1
Orthologs:
Mus musculus (house mouse) : Defb4 (defensin beta 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Defb4 (defensin beta 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : DEFB4A (defensin beta 4A)
Canis lupus familiaris (dog) : DEFB4A (defensin, beta 4A)
Sus scrofa (pig) : DEFB1 (defensin, beta 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl87,894,629 - 7,896,711 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl87,894,677 - 7,896,716 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl87,414,855 - 7,416,863 (-)EnsemblGRCh38hg38GRCh38
GRCh3887,894,677 - 7,896,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3787,752,199 - 7,754,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3687,789,609 - 7,791,647 (+)NCBINCBI36hg18NCBI36
Build 3487,789,608 - 7,791,647NCBI
Cytogenetic Map8p23.1NCBI
CHM1_187,817,745 - 7,819,911 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DEFB4A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348794
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.