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Gene: MDC1 (mediator of DNA damage checkpoint 1) Homo sapiens
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Symbol: MDC1
Name: mediator of DNA damage checkpoint 1
Description: Exhibits FHA domain binding activity; identical protein binding activity; and protein C-terminus binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining and intra-S DNA damage checkpoint. Localizes to focal adhesion and nuclear body. Biomarker of breast carcinoma; cervical cancer; lung carcinoma; and stomach carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781A0122; homologue to Drosophila photoreceptor protein calphotin; KIAA0170; mediator of DNA damage checkpoint protein 1; mediator of DNA-damage checkpoint 1; MGC166888; NFBD1; nuclear factor with BRCT domains 1
Orthologs:
Mus musculus (house mouse) : Mdc1 (mediator of DNA damage checkpoint 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mdc1 (mediator of DNA damage checkpoint 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mdc1 (mediator of DNA damage checkpoint 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MDC1 (mediator of DNA damage checkpoint 1)
Canis lupus familiaris (dog) : MDC1 (mediator of DNA damage checkpoint 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mdc1 (mediator of DNA damage checkpoint 1)
Sus scrofa (pig) : MDC1 (mediator of DNA damage checkpoint 1)
Chlorocebus sabaeus (African green monkey) : MDC1 (mediator of DNA damage checkpoint 1)
Heterocephalus glaber (naked mole-rat) : Mdc1 (mediator of DNA damage checkpoint 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl630,699,807 - 30,717,447 (-)EnsemblGRCh38hg38GRCh38
GRCh38630,699,807 - 30,717,988 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37630,667,584 - 30,685,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,775,563 - 30,793,437 (-)NCBINCBI36hg18NCBI36
Build 34630,775,563 - 30,790,934NCBI
Celera632,265,722 - 32,283,590 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef630,467,532 - 30,485,406 (-)NCBIHuRef
CHM1_1630,669,686 - 30,687,581 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MDC1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348817
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.