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Gene: GPSM1 (G protein signaling modulator 1) Homo sapiens
Symbol: GPSM1
Name: G protein signaling modulator 1
CRRD ID: 1348855
Description: Exhibits GDP-dissociation inhibitor activity. Involved in negative regulation of GTPase activity; negative regulation of guanyl-nucleotide exchange factor activity; and positive regulation of macroautophagy. Localizes to several cellular components, including Golgi apparatus; nucleoplasm; and plasma membrane. Colocalizes with Golgi membrane; cell cortex; and endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1810037C22Rik; activator of G-protein signaling 3; AGS3; AGS3 homolog; DKFZp727I051; G-protein signaling modulator 1; G-protein signaling modulator 1 (AGS3-like, C. elegans); G-protein signalling modulator 1 (AGS3-like, C. elegans); G-protein-signaling modulator 1
Mus musculus (house mouse) : Gpsm1 (G-protein signalling modulator 1 (AGS3-like, C. elegans))  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpsm1 (G-protein signaling modulator 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpsm1 (G protein signaling modulator 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GPSM1 (G protein signaling modulator 1)
Canis lupus familiaris (dog) : GPSM1 (G protein signaling modulator 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpsm1 (G protein signaling modulator 1)
Sus scrofa (pig) : GPSM1 (G protein signaling modulator 1)
Chlorocebus sabaeus (African green monkey) : GPSM1 (G protein signaling modulator 1)
Heterocephalus glaber (naked mole-rat) : Gpsm1 (G protein signaling modulator 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl9136,327,476 - 136,359,605 (+)EnsemblGRCh38hg38GRCh38
GRCh389136,327,539 - 136,359,605 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379139,221,932 - 139,254,057 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,348,726 - 138,372,493 (+)NCBINCBI36hg18NCBI36
Build 349136,504,741 - 136,528,509NCBI
Celera9109,736,118 - 109,768,993 (+)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9108,681,506 - 108,713,413 (+)NCBIHuRef
CHM1_19139,370,654 - 139,402,253 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GPSM1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348855
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.