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Gene: NUMB (NUMB endocytic adaptor protein) Homo sapiens
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Symbol: NUMB
Name: NUMB endocytic adaptor protein
Description: Exhibits cadherin binding activity. Involved in negative regulation of protein localization to plasma membrane and positive regulation of cell migration. Localizes to the clathrin-coated vesicle.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c14_5527; C14orf41; chromosome 14 open reading frame 41; FLJ31314; h-Numb; numb homolog; numb homolog (Drosophila); S171
Orthologs:
Mus musculus (house mouse) : Numb (NUMB endocytic adaptor protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Numb (NUMB, endocytic adaptor protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Numb (NUMB endocytic adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : NUMB (NUMB endocytic adaptor protein)
Canis lupus familiaris (dog) : NUMB (NUMB endocytic adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Numb (NUMB endocytic adaptor protein)
Sus scrofa (pig) : NUMB (NUMB endocytic adaptor protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381473,275,210 - 73,458,580 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371473,741,858 - 73,925,288 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361472,811,671 - 72,995,039 (-)NCBINCBI36hg18NCBI36
Build 341472,811,670 - 72,995,039NCBI
Celera1453,805,138 - 53,989,581 (-)NCBI
Cytogenetic Map14q24.2-q24.3NCBI
HuRef1453,907,407 - 54,092,058 (-)NCBIHuRef
CHM1_11473,681,206 - 73,864,710 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Comparative Map Data
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Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NUMB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348962
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.