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Gene: HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) Homo sapiens
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Symbol: HNRNPA1
Name: heterogeneous nuclear ribonucleoprotein A1
Description: Exhibits identical protein binding activity; nucleic acid binding activity; and protein domain specific binding activity. Involved in several processes, including cellular response to sodium arsenite; nucleocytoplasmic transport; and regulation of telomere maintenance via telomerase. Localizes to catalytic step 2 spliceosome; cytoplasm; and nucleoplasm. Implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Biomarker of Alzheimer's disease; hepatocellular carcinoma; and lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS19; ALS20; helix-destabilizing protein; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP A1-like 3; hnRNP core protein A1; hnRNP core protein A1-like 3; hnRNP-A1; HNRPA1; HNRPA1L3; IBMPFD3; MGC102835; nuclear ribonucleoprotein particle A1 protein; Putative heterogeneous nuclear ribonucleoprotein A1-like 3; single-strand DNA-binding protein UP1; single-strand RNA-binding protein; UP 1
Orthologs:
Mus musculus (house mouse) : Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1)
Pan paniscus (bonobo/pygmy chimpanzee) : HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)
Canis lupus familiaris (dog) : HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1)
Sus scrofa (pig) : HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)
Chlorocebus sabaeus (African green monkey) : HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)
Heterocephalus glaber (naked mole-rat) : Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1)
more info ...
Related Pseudogenes: AL391058.1   HNRNPA1P1   HNRNPA1P10   HNRNPA1P11   HNRNPA1P12   HNRNPA1P13   HNRNPA1P14   HNRNPA1P15   HNRNPA1P16   HNRNPA1P17   HNRNPA1P18   HNRNPA1P19   HNRNPA1P2   HNRNPA1P20   HNRNPA1P21   HNRNPA1P22   HNRNPA1P23   HNRNPA1P24   HNRNPA1P25   HNRNPA1P26   HNRNPA1P27   HNRNPA1P28   HNRNPA1P29   HNRNPA1P3   HNRNPA1P30   HNRNPA1P31   HNRNPA1P32   HNRNPA1P33   HNRNPA1P35   HNRNPA1P36   HNRNPA1P37   HNRNPA1P38   HNRNPA1P39   HNRNPA1P4   HNRNPA1P40   HNRNPA1P42   HNRNPA1P43   HNRNPA1P44   HNRNPA1P45   HNRNPA1P46   HNRNPA1P47   HNRNPA1P48   HNRNPA1P49   HNRNPA1P5   HNRNPA1P50   HNRNPA1P51   HNRNPA1P52   HNRNPA1P53   HNRNPA1P54   HNRNPA1P55   HNRNPA1P56   HNRNPA1P58   HNRNPA1P59   HNRNPA1P6   HNRNPA1P60   HNRNPA1P61   HNRNPA1P62   HNRNPA1P63   HNRNPA1P64   HNRNPA1P65   HNRNPA1P66   HNRNPA1P67   HNRNPA1P68   HNRNPA1P69   HNRNPA1P7   HNRNPA1P70   HNRNPA1P71   HNRNPA1P72   HNRNPA1P74   HNRNPA1P75   HNRNPA1P76   HNRNPA1P77   HNRNPA1P8   HNRNPA1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1254,280,193 - 54,287,088 (+)EnsemblGRCh38hg38GRCh38
GRCh381254,280,726 - 54,287,087 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371254,674,480 - 54,680,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,960,755 - 52,965,297 (+)NCBINCBI36hg18NCBI36
Build 341252,960,754 - 52,965,297NCBI
Celera1254,326,467 - 54,331,009 (+)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1251,713,759 - 51,718,301 (+)NCBIHuRef
CHM1_11254,641,212 - 54,647,610 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HNRNPA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1348965
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.