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Gene: POU3F3 (POU class 3 homeobox 3) Homo sapiens
Symbol: POU3F3
Name: POU class 3 homeobox 3
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in several processes, including metanephric nephron epithelium development; negative regulation of apoptotic process; and regulation of transcription, DNA-templated. Localizes to the nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: brain-1; brain-specific homeobox/POU domain protein 1; brn-1; BRN1; oct-8; octamer-binding protein 8; octamer-binding transcription factor 8; OTF-8; OTF8; POU domain, class 3, transcription factor 3; SNIBFIS
Mus musculus (house mouse) : Pou3f3 (POU domain, class 3, transcription factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pou3f3 (POU class 3 homeobox 3)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : POU3F3 (POU class 3 homeobox 3)
Canis lupus familiaris (dog) : POU3F3 (POU class 3 homeobox 3)
Sus scrofa (pig) : POU3F3 (POU class 3 homeobox 3)
Chlorocebus sabaeus (green monkey) : POU3F3 (POU class 3 homeobox 3)
Heterocephalus glaber (naked mole-rat) : Pou3f3 (POU class 3 homeobox 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2104,853,287 - 104,858,574 (+)Ensembl
GRCh38 Ensembl2104,854,115 - 104,858,574 (+)Ensembl
GRCh382104,854,115 - 104,858,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372105,471,969 - 105,473,471 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362104,838,401 - 104,839,903 (+)NCBINCBI36hg18NCBI36
Build 342104,930,486 - 104,931,989NCBI
Celera299,673,184 - 99,674,686 (+)NCBI
Cytogenetic Map2q12.1NCBI
HuRef299,242,289 - 99,243,259 (+)NCBIHuRef
CHM1_12105,475,993 - 105,480,141 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on POU3F3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349087
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.