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Gene: MYB (MYB proto-oncogene, transcription factor) Homo sapiens
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Symbol: MYB
Name: MYB proto-oncogene, transcription factor
Description: Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including positive regulation of T-helper cell differentiation; positive regulation of histone methylation; and regulation of transcription by RNA polymerase II. Localizes to the cytosol and nucleoplasm. Biomarker of adult T-cell leukemia and precursor B lymphoblastic lymphoma/leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-myb; c-myb protein (140 AA); c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; c-myb_CDS; Cmyb; efg; oncogene AMV; proto-oncogene c-Myb; transcriptional activator Myb; v-myb avian myeloblastosis viral oncogene homolog
Orthologs:
Mus musculus (house mouse) : Myb (myeloblastosis oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Myb (MYB proto-oncogene, transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myb (MYB proto-oncogene, transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MYB (MYB proto-oncogene, transcription factor)
Canis lupus familiaris (dog) : MYB (MYB proto-oncogene, transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myb (MYB proto-oncogene, transcription factor)
Sus scrofa (pig) : MYB (MYB proto-oncogene, transcription factor)
Chlorocebus sabaeus (green monkey) : MYB (MYB proto-oncogene, transcription factor)
Heterocephalus glaber (naked mole-rat) : Myb (MYB proto-oncogene, transcription factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl6135,181,308 - 135,219,173 (+)Ensembl
GRCh386135,181,308 - 135,219,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376135,502,453 - 135,540,311 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366135,544,146 - 135,582,003 (+)NCBINCBI36hg18NCBI36
Build 346135,544,145 - 135,582,002NCBI
Celera6136,242,804 - 136,280,663 (+)NCBI
Cytogenetic Map6q23.3NCBI
HuRef6133,066,684 - 133,104,587 (+)NCBIHuRef
CHM1_16135,764,731 - 135,802,560 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MYB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349179
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.