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Gene: IL12RB1 (interleukin 12 receptor subunit beta 1) Homo sapiens
Symbol: IL12RB1
Name: interleukin 12 receptor subunit beta 1
Description: Contributes to cytokine receptor activity; interleukin-12 receptor binding activity; and interleukin-23 binding activity. Involved in several processes, including cellular response to interferon-gamma; positive regulation of activated T cell proliferation; and positive regulation of defense response to virus by host. Localizes to interleukin-12 receptor complex and interleukin-23 receptor complex. Implicated in primary immunodeficiency disease. Biomarker of primary biliary cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD212; cluster of differentiation 212; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12R-BETA1; IL-12RB1; IL12RB; IMD30; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain; interleukin-12 receptor subunit beta-1; MGC34454
Mus musculus (house mouse) : Il12rb1 (interleukin 12 receptor, beta 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il12rb1 (interleukin 12 receptor subunit beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il12rb1 (interleukin 12 receptor subunit beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IL12RB1 (interleukin 12 receptor subunit beta 1)
Canis lupus familiaris (dog) : IL12RB1 (interleukin 12 receptor subunit beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il12rb1 (interleukin 12 receptor subunit beta 1)
Sus scrofa (pig) : IL12RB1 (interleukin 12 receptor subunit beta 1)
Chlorocebus sabaeus (African green monkey) : IL12RB1 (interleukin 12 receptor subunit beta 1)
Heterocephalus glaber (naked mole-rat) : Il12rb1 (interleukin 12 receptor subunit beta 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1918,058,995 - 18,098,944 (-)EnsemblGRCh38hg38GRCh38
GRCh381918,058,994 - 18,099,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,170,371 - 18,197,806 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,031,371 - 18,058,697 (-)NCBINCBI36hg18NCBI36
Build 341918,042,372 - 18,058,697NCBI
Celera1918,072,103 - 18,099,423 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,735,230 - 17,761,934 (-)NCBIHuRef
CHM1_11918,169,404 - 18,209,196 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL12RB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349194
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.