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Gene: ZC4H2 (zinc finger C4H2-type containing) Homo sapiens
Symbol: ZC4H2
Name: zinc finger C4H2-type containing
Description: This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This gene has been identified as a potential candidate for X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HCA127; hepatocellular carcinoma-associated antigen 127; KIAA1166; MCS; Miles-Carpenter syndrome (mental retardation, X-linked, syndromic-4, with congenital contractures and low fingertip arches); Miles-Carpenter X-linked mental retardation syndrome; MRXS4; Wieacker-Wolff syndrome; WRWF; WWS; zinc finger C4H2 domain-containing protein; zinc finger, C4H2 domain containing
Mus musculus (house mouse) : Zc4h2 (zinc finger, C4H2 domain containing)  MGI  Alliance
Rattus norvegicus (Norway rat) : Zc4h2 (zinc finger C4H2-type containing)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zc4h2 (zinc finger C4H2-type containing)
Pan paniscus (bonobo/pygmy chimpanzee) : ZC4H2 (zinc finger C4H2-type containing)
Canis lupus familiaris (dog) : ZC4H2 (zinc finger C4H2-type containing)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zc4h2 (zinc finger C4H2-type containing)
Sus scrofa (pig) : ZC4H2 (zinc finger C4H2-type containing)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X64,915,802 - 65,034,744 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X64,135,682 - 64,254,624 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X64,052,986 - 64,113,061 (-)NCBINCBI36hg18NCBI36
Build 34X63,919,282 - 63,979,357NCBI
CeleraX64,483,059 - 64,601,403 (-)NCBI
Cytogenetic MapXq11.2NCBI
HuRefX57,960,742 - 58,079,091 (-)NCBIHuRef
CHM1_1X64,028,323 - 64,147,256 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ZC4H2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349237
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.