Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PLP2 (proteolipid protein 2) Homo sapiens
Analyze
Symbol: PLP2
Name: proteolipid protein 2
Description: This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A4; A4 differentiation-dependent protein; A4-LSB; A4LSB; differentiation-dependent protein A4; intestinal membrane A4 protein; MGC126187; proteolipid protein 2 (colonic epithelium-enriched)
Orthologs:
Mus musculus (house mouse) : Plp2 (proteolipid protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plp2 (proteolipid protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plp2 (proteolipid protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PLP2 (proteolipid protein 2)
Canis lupus familiaris (dog) : PLP2 (proteolipid protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plp2 (proteolipid protein 2)
Sus scrofa (pig) : PLP2 (proteolipid protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X49,171,898 - 49,175,235 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X49,028,184 - 49,031,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,915,217 - 48,918,382 (+)NCBINCBI36hg18NCBI36
Build 34X48,784,643 - 48,787,808NCBI
CeleraX52,632,900 - 52,636,185 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,685,454 - 46,688,739 (+)NCBIHuRef
CHM1_1X49,060,509 - 49,063,794 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PLP2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349250
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.