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Gene: PLP2 (proteolipid protein 2) Homo sapiens
Symbol: PLP2
Name: proteolipid protein 2
Description: This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A4; A4 differentiation-dependent protein; A4-LSB; A4LSB; differentiation-dependent protein A4; intestinal membrane A4 protein; MGC126187; proteolipid protein 2 (colonic epithelium-enriched)
Mus musculus (house mouse) : Plp2 (proteolipid protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plp2 (proteolipid protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plp2 (proteolipid protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PLP2 (proteolipid protein 2)
Canis lupus familiaris (dog) : PLP2 (proteolipid protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plp2 (proteolipid protein 2)
Sus scrofa (pig) : PLP2 (proteolipid protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X49,171,898 - 49,175,235 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X49,028,184 - 49,031,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,915,217 - 48,918,382 (+)NCBINCBI36hg18NCBI36
Build 34X48,784,643 - 48,787,808NCBI
CeleraX52,632,900 - 52,636,185 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,685,454 - 46,688,739 (+)NCBIHuRef
CHM1_1X49,060,509 - 49,063,794 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PLP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349250
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.