Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MIR124-1 (microRNA 124-1) Homo sapiens
Analyze
Symbol: MIR124-1
Name: microRNA 124-1
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-124-1; MIR124A; MIR124A1; MIRN124-1; MIRN124A1
Orthologs:
Mus musculus (house mouse) : Mir124a-1 (microRNA 124a-1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mir124-1 (microRNA 124-1)  Alliance
Canis lupus familiaris (dog) : MIR124-1 (microRNA mir-124-1)
Sus scrofa (pig) : MIR124A-2 (microRNA mir-124a-2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl89,903,388 - 9,903,472 (-)EnsemblGRCh38hg38GRCh38
GRCh3889,903,388 - 9,903,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3789,760,898 - 9,760,982 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3689,798,307 - 9,798,391 (-)NCBINCBI36hg18NCBI36
Celera88,887,241 - 8,887,325 (-)NCBI
Cytogenetic Map8p23.1NCBI
HuRef88,689,475 - 8,689,559 (-)NCBIHuRef
CHM1_189,826,429 - 9,826,513 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers

Expression


Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
 
More on MIR124-1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349266
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-30
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.