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Gene: PON1 (paraoxonase 1) Homo sapiens
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Symbol: PON1
Name: paraoxonase 1
CRRD ID: 1349272
Description: Exhibits several functions, including aryldialkylphosphatase activity; arylesterase activity; and protein homodimerization activity. Involved in several processes, including phosphatidylcholine metabolic process; positive regulation of binding activity; and positive regulation of transport. Localizes to spherical high-density lipoprotein particle. Implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); eye disease (multiple); and inflammatory bowel disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A-esterase 1; aromatic esterase 1; arylesterase 1; arylesterase B-type; ESA; esterase A; K-45; MVCD5; paraoxonase B-type; PON; PON 1; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1
Orthologs:
Mus musculus (house mouse) : Pon1 (paraoxonase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pon1 (paraoxonase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pon1 (paraoxonase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PON1 (paraoxonase 1)
Canis lupus familiaris (dog) : PON1 (paraoxonase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pon1 (paraoxonase 1)
Sus scrofa (pig) : PON1 (paraoxonase 1)
Chlorocebus sabaeus (African green monkey) : PON1 (paraoxonase 1)
Heterocephalus glaber (naked mole-rat) : Pon1 (paraoxonase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl795,297,676 - 95,324,532 (-)EnsemblGRCh38hg38GRCh38
GRCh38795,297,676 - 95,324,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37794,927,669 - 94,953,884 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,764,924 - 94,791,780 (-)NCBINCBI36hg18NCBI36
Build 34794,571,638 - 94,598,495NCBI
Celera789,626,366 - 89,652,590 (-)NCBI
Cytogenetic Map7q21.3NCBI
HuRef789,534,701 - 89,560,922 (-)NCBIHuRef
CHM1_1794,857,684 - 94,883,916 (-)NCBICHM1_1
CRA_TCAGchr7v2794,256,665 - 94,282,884 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PON1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1349272
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.